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Modified Microspheres
Microsphere Modifications
Capture Reagents: Our microsphere modification services are customized to your needs. You can choose the volume, the xMAP microsphere designation, and the capture reagent. We have no affiliation with reagent manufacturers, so we will bulk couple the reagent of your choice, without regard to its original source.
Alternative Functionalities: We also provide various chemical modifications that give you even more options for assay development and optimization. We have developed several alternative surface chemistries that can be used for more specific research needs. The choice of chemical modification depends on the functionality of your capture reagent. The following table classifies the capture reagents that could be used for different assay formats.
Alternatively Functionalized Beads
| Functionality | Complementary Functionality | Example Biomolecule | Application | Utility |
|---|---|---|---|---|
| Antibodies | Antigens | Proteins, Peptides | Immunoassays/enzyme activity assays |
Expression analysis, detection and diagnosis |
| Antigens | Antibodies | Proteins, Peptides | Diagnosis, serology, activity determination | |
| Oligonucleotides | Complementary Sequences | Oligonucleotides, PCR Amplicons | Nucleic acid assays | Expression analysis, detection and diagnosis |
| Avidin — Low Capacity | Biotin — Conjugated Molecules | Proteins, Peptides, Oligonucleotides | Immunoassays/nucleic acid assays/receptor ligand assays/enzyme ctivity assays |
Expression analysis, detection, diagnosis, Peptide screening, synthetic or recombinant antibody screening |
| Avidin — High Capacity | Biotin — Conjugated Molecules | Proteins, Peptides, Oligonucleotides | ||
| Hydrazide | Carboxyl Groups, Aldehyde Groups | Proteins, Peptides, Glycoproteins, Carbohydrates | Immunoassays/ receptor ligand assays |
Peptide screening, synthetic or recombinant antibody screening |
| Maleimide | Sulfhydryl Groups | Proteins, Peptides | ||
| Species — Specific Anti-Immunoglobulin |
Antigen — specific Antibody |
Restricted Availability Antibodies | Immunoassays | Antibody screening, vaccine efficacy testing |